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And when the liver notices it’s making less cholesterol, it creates receptors that eliminate cholesterol in the blood, Blumenthal adds

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What to Expect (Phase by Phase) Weeks 1–3: Adjustment Mild water retention and bloating (GH effect — settles by week 3-4) Morning joint stiffness or slight puffiness in hands (common, dose-related) Possible fatigue from stronger overnight GH pulses Some users notice improved sleep quality immediately Weeks 3–8: Building Phase Improved recovery between workouts becomes noticeable Gradual lean mass improvements — this is not a fast-acting protocol Reduced body fat, particularly visceral fat with extended use Skin quality improvements (GH + IGF-1 effect on collagen) Increased hunger is common — your metabolism is running higher Weeks 8–16: Full Effect Strength and endurance improvements compound Body composition changes become clearly visible Sleep quality, hair, and skin improvements often cited by long-term users Some users notice joint comfort improvements (IGF-1 has cartilage effects) Side Effects and How to Manage Them Water retention: Most common early on