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Dimet-Wiley, Wu, and colleagues, also publishing in Scientific Reports in 2022, found that NNMT inhibition combined with calorie restriction altered gut microbiome composition in diet-induced obese mice — suggesting systemic metabolic effects that extend beyond adipose tissue, though the clinical significance in humans is unknown
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Another aspect of the invention pertains to a method of providing muscular therapy by administering a therapeutically effective amount of one or more cations
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