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Neurosci Lett (2007) 422:24–9.10.1016/j.neulet.2007.05.025 87 WollackJBMakoriBAhlawatSKoneruRPicinichSCSmithAet alCharacterization of folate uptake by choroid plexus epithelial cells in a rat primary culture model
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Activated MG engage in a dual role: on one hand, they phagocytose cellular debris and clear damaged cells, while on the other hand, they express immunoglobulin Fc receptors (such as CD16/CD32) and release pro-inflammatory cytokines (e.g., tumor necrosis factor-α [TNF-α], interleukin [IL]-1β, IL-6), metabolic enzymes (such as inducible nitric oxide synthase [iNOS]), nitric oxide (NO), and metabolic byproducts (such as reactive oxygen species [ROS]) to drive inflammatory processes and expedite neuronal demise in response to pathological changes or various stimuli, including lipopolysaccharide (LPS) and interferon (IFN)-γ (Yang et al., 2022b)
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